Thematic Issue: Infection and Immunity Research at the University of Maryland, Baltimore

This Thematic Issue is a representative sampling of the research performed in 2016 at the University of Maryland Baltimore (UMB) in the area of infection and immunity, historically favored subjects of investigation at this 209-year old institution. Twenty two research articles, minireviews and commentaries provide a time capsule of research on 'current’ infectious agents ranging from Ebola to Clostridium difficile, from novel vaccine approaches ongoing at the internationally renowned UMB Center for Vaccine Development, to comparative genomics studies of protozoan parasites ongoing at the UMB Institute for Genome Science. The UMB campus is located near the Inner Harbor of the city of Baltimore, Maryland, at the heart of one of the most research-intensive areas for biomedical sciences in the United States of America and the world.


Editorial: Infection and immunity research at the University of Maryland, Baltimore
James B. Kaper, Martin F. Flajnik, Harry L.T. Mobley
DOI: 10.1093/femspd/ftw100




Cell targeting antibodies in immunity to Ebola
Alan Schmaljohn, George K. Lewis
DOI: 10.1093/femspd/ftw021


The Rickettsia type IV secretion system: unrealized complexity mired by gene family expansion
Joseph J. Gillespie, Isabelle Q.H. Phan, Timothy P. Driscoll, Mark L. Guillotte, Stephanie S. Lehman, Kristen E. Rennoll-Bankert, Sandhya Subramanian, Magda Beier-Sexton, Peter J. Myler, M. Sayeedur Rahman, Abdu F. Azad
DOI: 10.1093/femspd/ftw058


Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire
Nevil J. Singh
                            DOI: 10.1093/femspd/ftw092


Enhanced allergic responsiveness after early childhood infection with reespiratory viruses: Are long-lived alternatively activated macrophages the missing link?
Achsah D. Keegan, Kari Ann Shirey, Dayanand Bagdure, Jorge Blanco, Rose M. Viscardi, Stefanie N. Vogel
                            DOI: 10.1093/femspd/ftw047


Pathogenesis of Candida albicans biofilm
Christina Tsui, Eric F. Kong, Mary Ann Jabra-Rizk
DOI: 10.1093/femspd/ftw018

Pathogenenic effects of glucosyltransferase from Clostridium difficile toxins
Yongrong Zhang, Hanping Feng
DOI: 10.1093/femspd/ftw024


The oncolytic virus ΔPK has multimodal anti-tumour activity
Laure Aurelian, Dominique Bollino, Aric Colunga
DOI: 10.1093/femspd/ftw050


Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection
Irina V. Tiper, James E. East, Priyanka B. Subrahmanyam, Tonya J. Webb
DOI: 10.1093/femspd/ftw063


Pertussis leukocytosis: mechanisms, clinical relevance and treatment
Nicholas H. Carbonetti
DOI: 10.1093/femspd/ftw087


Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria
Ellen E. Higginson, James E. Galen, Myron M. Levine, Sharon M. Tennant
DOI: 10.1093/femspd/ftw078


Control of autoimmune inflammation by celastrol, a natural triterpenoid
Shivaprasad H. Venkatesha, Steven Dudics, Brian Astry, Kamal D. Moudgil
DOI: 10.1093/femspd/ftw059


Research Articles

Characterization of a multicomponent live, attenuated Shigella flexneri vaccine
BreOnna C. DeLaine, Tao Wu, Christen L. Grassel, Avital Shimanovich, Marcela F. Pasetti, Myron M. Levine, Eileen M. Barry
DOI: 10.1093/femspd/ftw034

Differential adapter recruitment by TLR2 co-receptors
Wenji Piao, Lisa W. Ru, Vladmir Y. Toshchakov
DOI: 10.1093/femspd/ftw043


Poor biofilm-forming ability and long-term survival of Salmonella Typhimurium ST313
Girish Ramachandran, Komi Aheto, Mark E. Shirtiff, Sharon M. Tennant
DOI: 10.1093/femspd/ftw049


Alterations in cellular metabolism modulate CD1-mediated NKT-cell responses
Tonya J. Webb, Gregory B. Carey, James E. East, Wenji Sun, Dominique R. Bollino, Amy S. Kimball, Randy R. Brutkiewicz
                            DOI: 10.1093/femspd/ftw055

Type IV pili promote early biofilm formation by Clostridium difficile
Grace A, Maldarelli, Kurt H, Piepenbrink, Alison J. Scott, Jeffrey A. Frieberg, Yang Song, Yvonne Achermann, Robert K. Ernst, Mark E. Shirtliff, Eric J. Sundberg, Michael S. Donnenberg, Erik C. von Rosenvinge
DOI: 10.1093/femspd/ftw061


Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection
Zhiyong Yang, Lianfa Shui, Hua Yu, Yongrong Zhang, Kevin Chen, Ashley Saint Fleur, Guang Bai, Hanping Feng
DOI: 10.1093/femspd/ftw078


Norharmane matrix enhances detection of endotoxin by MALDI-MS for simultaneous profiling of pathogen, host, and vector systems
Alison J. Scott, Bryn Flinders, Joanna Cappell, Tao Ling, Rebecca S. Pelc, Bao Tran, David P.A. Kilgour, Ron M.A. Heeren, David R. Goodlett, Robert K. Ernst
DOI: 10.1093/femspd/ftw097

Intracellular disassembly and activity of pertussis toxin require interaction with ATP
Roger D. Plaut, Karen M. Scanlon, Michael Taylor, Ken Teter, Nicholas H. Carbonetti
DOI: 10.1093/femspd/ftw065


Highly active antiretroviral therapy reduces pulmonary IL -8 in HIV-positive women smokers
Gregory H. Taylor, Adrienne A. Williams, Alfredo Garzino-Demo
DOI: 10.1093/femspd/ftv115



Genome diversity of Shigella boydii
Dane A. Kania, Tracey H. Hazen, Anowar Hossain, James P. Nataro, David A. Rasko
DOI: 10.1093/femspd/ftw027


Short Communications

Annotated draft genome sequences of three species of CryptosporidiumCryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1
Olukemi O. Igeonu, Marcus C. Chibucos, Joshua Orvis, Qi Su, Kristin Elwin, Fengguang Guo, Haili Zhang, Lihua Xiao, Mingfei Sun, Rachel M. Chalmers, Claire M. Fraser, Guan Zhu, Jessica C. Kissinger, Giovanni Widmer, Joana C. Silva
DOI: 10.1093/femspd/ftw080